ENHANCING REINFORCEMENT LEARNING MODELS BY INCLUDING DIRECT AND INDIRECT PATHWAYS IMPROVES PERFORMANCE ON STRIATAL DEPENDENT TASKS.

Enhancing reinforcement learning models by including direct and indirect pathways improves performance on striatal dependent tasks.

A major advance in understanding learning behavior stems from experiments showing that reward learning requires dopamine inputs to striatal neurons and arises from synaptic plasticity of cortico-striatal synapses.Numerous reinforcement learning models mimic this dopamine-dependent synaptic plasticity by using the reward prediction error, which rese

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hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature

To gain Boys Jackets insight into the cellular and molecular cues that promote neurovascular co-patterning at the earliest stages of human embryogenesis, we developed a human embryonic stem cell model to mimic the developing epiblast.Contact of ectoderm-derived neural cells with mesoderm-derived vasculature is initiated via the neural crest (NC), n

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